The EU Blue Economy Report, now in its sixth edition, continues to examine the size and importance of the Blue Economy in the European Union. Its primary goal is to assist policymakers and stakeholders in promoting sustainable development of oceans and coastal resources, aligning with the European Green Deal's principles. The report aims to provide economic insights and inspire investors. In this edition, the report focuses on analyzing data, trends, and factors influencing the traditional Blue Economy sectors, as well as Blue Biotechnology and Ocean Energy. It also briefly discusses the impacts of Russia's invasion of Ukraine on some Blue Economy sectors. Additionally, the report delves into the energy transition within the Blue Economy, evaluating greenhouse gas emissions in relation to various species, fishing methods, and production stages. Lastly, the report explores climate change and its effects on coastal areas, summarizing findings about future coastal flood impacts, adaptation, and ecosystem services along the EU-27 coastline.