Activities shall develop smart breeding programmes and/or tailor feeding formulas and technologies for conventional and organic aquaculture – for marine and/or freshwater - targeting animal health (contributing to disease resistance) and welfare, different production systems, feeding efficiency, resilience and climate change mitigation - when applicable, including related traits and possible links between them (synergies, trade-offs) -, zero waste, by-products valorisation following circularity principles and organoleptic and nutritional values of seafood optimisation. Efforts to close the reproduction cycle of economically important species should be considered. In addition, activities shall explore the potential of the microbiome on health and productivity of farmed species.[3] Activities shall consider sound cost-effective production methods and profitability, testing, demonstrating and upscaling of the production processes to pre-commercial product. Regulatory authority and consumers should also be consulted, addressing their concerns and demands. The use of Internet of Things (IoT) and Artificial Intelligence (AI) should be considered. The participation of deep-tech start-ups is encouraged. Activities shall develop a set of indicators to monitor and measure progress towards the expected impacts as listed in the call text and in particular the improvement of the production systems that increases productivity, resilience and sustainability. The interdisciplinary and cross-sectorial nature of the project should also apply to training activities improving the professional skills and competencies and supporting the creation of new jobs in the blue economy.